Cannabis, psychosis and schizophrenia

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Depending on the kind that has been used, and your susceptibility to it, cannabis can cause psychotic experiences such as hallucinations, fantasies, depersonalisation and derealisation (feeling out of touch with yourself or your surroundings), feeling a loss of control, fear of dying, irrational panic and paranoid ideas.

In theory, cannabis may cause a psychotic reaction in the following ways:

  • Taking a high dose may cause a psychotic reaction with hallucinations or confusion, which goes away after the drug is stopped.
  • It may lead to a long-term psychosis that does not go away when the drug is stopped.
  • Long-term use may induce psychosis that gets a bit better if the drug is stopped.
  • Cannabis may be a trigger for serious mental illness, such as schizophrenia.  

Among people who already have a diagnosis of psychotic illness, cannabis users are thought to experience more psychotic relapses. Again, experience depends on the strength of the type used as well as frequency of use.

Research in young people suggests that using cannabis as a teenager increases the likelihood of experiencing symptoms of schizophrenia in adulthood, and early cannabis use (by age 15) confers greater risk than using it later on (by age 18). This research suggests that, although the majority of adolescents are not harmed by using cannabis, a small minority are.

Results of a Swedish study suggest that cannabis increases the risk of schizophrenia by 30 per cent. However, this does not appear to be reflected in the figures for schizophrenia in the population in general, which have remained constant over a long period. This study also concludes that cannabis has few harmful effects overall, but that there is a potentially serious risk to the mental health of people who use cannabis, particularly in the presence of other risk factors for schizophrenia.

Researchers who examined further published evidence on cannabis and psychosis in 2004 came to the conclusion that, for any individual, using cannabis doubles the risk of developing schizophrenia in later life, and, for the population as a whole, elimination of cannabis use would reduce the incidence of schizophrenia by about 8 per cent, if you assume that it has a causal effect. Cannabis use alone does not cause psychosis, but it is one of the things that may contribute to its development; therefore, using cannabis increases the risk, and some cases of psychosis could be prevented by discouraging cannabis use among vulnerable young people. A response to this report further suggested that adolescents may be more vulnerable to the adverse effects of cannabis than are adults because their brains are still developing. [16] A further study concluded that cannabis use increases the risk of psychotic symptoms in young people, but has a much stronger effect in those with evidence of a predisposition for psychosis (such as a family history of mental illness).

Support for this suggestion is provided by a study in young people of a particular enzyme called COMT (catechol-O-methyl transferase), which is involved in the regulation of the brain chemical dopamine (psychosis is thought to be associated with high levels of dopamine). COMT is produced by a gene, two variants of which occur in the population, and produce two forms of the enzyme, which break down dopamine to different degrees. As with all genes, people inherit one copy from each parent. The study found that people who inherited two ‘good’ subtypes could use cannabis without it affecting their mental health; those with one of each subtype were at slightly more risk of psychosis with cannabis; while in those who had two ‘bad’ subtypes the risk was increased ten-fold.

A further study, reported in The Lancet in July 2007, which analysed reports from 35 published studies, found ‘a consistent increase in incidence of psychosis outcomes in people who had used cannabis’. Their analysis suggested that there was a 40 per cent increase in risk of psychosis in study participants who had ever used cannabis. Effects were larger with frequent use, with an increased risk of up to 200 per cent in those who used cannabis most heavily.

In a written answer to the House of Commons on 18 July 2005, Rosie Winterton MP said that admissions associated with cannabis use rose to 710 in 2003-2004, from 580 in the previous two years. There is some evidence that, since cannabis was down-graded in the UK from a class B to a class C drug in January 2004, psychiatrists have seen further increasing numbers of people being hospitalised with psychotic episodes associated with cannabis use. This is in spite of the fact that overall numbers of people using cannabis have fallen, and a further indication that of those people who use cannabis, more of them are using strong varieties which are more likely to cause adverse effects on mental health.

 


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