Does the Flu Cause Schizophrenia?

0 ratings

Video Description

"This is a question puzzling physiologists worldwide, and a correlation which has been documented through countless studies. This video investigates the newly observed correlation between prenatal influenza exposure and adult schizophrenia onset. Primary research indicates the possible cause of this correlation may be the mother or fetus’ immune response in reaction to the virus itself. Please see below references for more information on mechanisms and evidence observed.

This video was made by Elise Granton, Roshni Patel, Nadine Islam, Omar Shawaf and Erin Harvey

Copyright McMaster University 2016

References:

Aronsson, F., Lannebo, C., Paucer, M., Brask, J., Kristensson, K., Karlsson, H. (2002). Persistence of viral RNA in the brain of spring to mice infected with influenza A/WSN/33 virus during pregnancy. J NeuroViro. 8:353-357.

Boksa, P. (2008). Naternal infection during pregnancy and schizophrenia. J psychiatry Neurosci. 33(3): 183-185.

Brown, A. S. (2006). Prenatal Infection as a Risk Factor for Schizophrenia. Schizophrenia Bulletin, 32(2), 200–202.

Brown, A. S., & Derkits, E. J. (2010). Prenatal Infection and Schizophrenia: A Review of Epidemiologic and Translational Studies. The American Journal of Psychiatry, 167(3), 261–280.

Ellaithy, A., Younkin, J., González-Maeso, J., & Logothetis, D. E. (2015). Positive allosteric modulators of metabotropic glutamate 2 receptors in schizophrenia treatment. Trends in neurosciences, 38(8), 506-516.

Gilmore, J., Jarskog, L., Vadlamudi, S., Lauder, J. (2004). Prenatal infection and risk for schizophrenia: IL-1b, IL-6, and TNFa inhibit cortical neuron dendrite development. Neuropsychopharm. 29:1221-1229.

HYPERLINK ""http://doi.org/10.1176/appi.ajp.2009....""

Irving, W., James, D., Stephenson, T., Laing, P., Jameson, C., Boon, A., Zambon, M. (2000). Influenza virus infection in the second and third trimesters of pregnancy: a clinical and seroepidemiological study. Brit. J. of Obstet. and Gynaeco. 107: 1282-1289.

Javitt, D. C. (2014). Balancing therapeutic safety and efficacy to improve clinical and economic outcomes in schizophrenia: A clinical overview. American Journal of Managed Care, 20(8), 160-165.

Leweke, F. M., Gerth, C. W., Koethe, D., Klosterkötter, J., Ruslanova, I., Krivogorsky, B., ... & Yolken, R. H. (2004). Antibodies to infectious agents in individuals with recent onset schizophrenia. European archives of psychiatry and clinical neuroscience, 254(1), 4-8.

Lofano, G., Kumar, A., Finco, O., Del Giudice, G., & Bertholet, S. (2015). B cells and functional antibody responses to combat influenza. Immunotherapies and Vaccines, 336.

Torrey, E. F., Miller, J., Rawlings, R., & Yolken, R. H. (1997). Seasonality of births in schizophrenia and bipolar disorder: a review of the literature.Schizophrenia research, 28(1), 1-38.

van Os J, Kapur S. Schizophrenia. Lancet. 2009;374(9690): 635-645."

Quotes

"There can be life after schizophrenia: in my own case, nearly thirty years of a very satisfying and rewarding, though not always easy, existence."

Christine

MoreSend us your Quotes


Tips & Hints

  • Spot the signs of an acute schizophrenic episode

    Learning to recognise the signs that you’re becoming unwell can help you manage your illness. These signs can include losing your app...
    More
  • Avoid drugs and alcohol

    While alcohol and drugs may provide short-term relief from your symptoms of schizophrenia, they are likely to make your symptoms worse ...
    More
  • Take your medication

    It is important to take your medication as prescribed, even if you don’t start to feel better immediately. Continuous medication can ...
    More
  • Have regular reviews

    As part of the care program approach, you will be in contact with your healthcare team regularly. A good relationship with the team mea...
    More
  • Self-care

    Self-care is an integral part of daily life. It means that you take responsibility for your own health and wellbeing with support from ...
    More
  • More Tips & Hints